With minimized manual operations and the ability to run multiple ReleGO™ systems in parallel, the users can screen more test samples in a shorter amount of time. Automated testing protocols save hours of manual work and the smaller skin tissue discs needed for REVex™ chip allow for savings on biomaterials. The microfluidic design ensures precise flow rates and prevents undesired accumulation for accurate results. In addition, the viability of real human tissue explants can be extended up to 2 times for long-term studies.