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Tissue Testing 2.0: Get the Scoop on Overcoming Old School Issues

[May 2023 Edition]

The three standout features of ReleGO™& REVex

REVIVO BioSystems’ platform, ReleGO™ and REVex™, incorporates highly engineered microfluidic technology that surpasses the constraints of ex vivo and in vitro traditional methods, owing to its three distinctive attributes.

Mimicking blood flow. ReleGO™ stands out with its unparalleled capability to mimic the function of the blood flow, enabling the creation of highly realistic in vivo-like environments for 4D in vitro and ex vivo study of active ingredients and product formulations. This adds a new dimension to your testing, allowing the examination of the mechanistic action resulting from the interaction between the chemical compounds and the skin, which was previously unattainable in 3D in vitro platforms.

Maintaining tissues & test samples at human body temperature. The REVex™ microfluidic chips, housing 3D tissue cultures and test samples, are securely placed on the heating pads of the ReleGO™, which are calibrated to maintain the medium flowing under the tissue culture at 37°C. This effectively emulates the physiological temperature of the human body throughout the testing period. The heating function can be switched off if you intend to run the study at room temperature.

No more late nights.The ReleGO™ & REVex™ platform eliminates the need for manual sampling. Its fully automated fractions collection enables convenience and time-accuracy in collecting samples of the outflow medium for post-processing analysis. Through its touch screen interface, it offers users a friendly and intuitive experience. Simply follow the step-by-step instructions on the menu to select your desired experiment duration, time intervals, flow rate, and temperature settings.

To learn more about the application of ReleGO™ and REVex™, watch this YouTube video. For further inquiries about our technology, contact our team at

Recent Updates

Featured in Personal Care Magazine

Our article "Skin penetration: next generation in vitro testing" has been published in the April 2023 digital edition of the Personal Care Magazine.

The article addresses the challenges associated with diffusion cell apparatus. It highlights how REVIVO BioSystems’ 4D skin-on-chip instrument, utilizing our proprietary microfluidic technology, overcomes the limitations of traditional methods for skin penetration studies and in vitro release testing of active compounds. You can read the full article here.

REVIVO BioSystems’ new lab

To support our growing operations, we have recently established a new lab facility. Here, our team of experts specializing in 4D tissue models will continue to develop cutting-edge solutions customized to meet the specific requirements of our customers. This expanded laboratory space enables us to elevate our Dare-to-Act services, tackle complex challenges, and uncover novel scientific insights to provide you with unparalleled access to the most realistic human tissue model solutions & empower your claims differentiation.

(Check out our Careers page for new opportunities to join our growing team.)

Join us at the 25th World Congress of Dermatology 2023

Join us at the Free Communication session “Translational science” on 5 July, Room 327 from 9:30 to 10:50 AM to hear from our Head of Ex Vivo & In Vitro Testing, Dr Sebastien Teissier.

Dr Sebastien Teissier will share his valuable insights on 2 exciting topics:

Topic 1: “REVskin, a skin-on-chip equivalent (SoCE) with advanced blood-flow mimicry, represents a significant improvement in 3D culture models for wound-healing and skin-aging studies”

Topic 2: “Infinite and finite dose permeation of small molecules through biological and synthetic skin simulants using an organ-on-chip platform”

That’s not all. Make sure to visit us at our Booth B06, where you can experience a live demo of our next generation 4D skin-on-chip platform technology. Our team will be available to answer any questions you may have.

Don’t miss out on this opportunity to witness the latest innovation in in vitro and ex vivo skin research. See you at the World Congress of Dermatology 2023!

Upcoming events

3-8 July | Singapore | Booth B06

SCSS 12th Suppliers Day 2023

5 September | Singapore

7-9 November | Bangkok | Booth P38


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